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  • 予人玫瑰，手有余香：加拿大新天地工作移民诚聘求职顾问&行业导师！
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  • 予人玫瑰，手有余香：加拿大新天地工作移民诚聘求职顾问&行业导师！

@Las Vegas

I see. Is this the one?

micah(mica)
A Phase III Confirmatory Study of K-237 - Full Text View.
Full Story:
https://clinicaltrials.gov/ct2/show/NCT05056883
(#14209639@0)
Last Updated: 2021-12-23
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Replies, comments and Discussions:

  • 枫下家园 / 医药保健 / FDA昨天和今天分别批准了辉瑞和默克的抗新冠新药，辉瑞的要有89%有效率而且是针对高危人群，默克的临床效果不错（超过50%)，不过大规模实验有效率下降到33%。 -coolrock(coolrock); 2021-12-23 (#14209158@0)
    • 授试群体多大？ -shunshunshun(顺顺顺); 2021-12-23 (#14209164@0)
      • 辉瑞的2/3期临床超过1千人，默克的3期只有300多人，因为效果很明显，所以第三方建议停止实验（对参与实验者没有真正给药的人不公平）。默克后来继续大规模实验，超过3000人，效果下降很多。 -coolrock(coolrock); 2021-12-23 (#14209172@0)
        • 法国退货了，莫克的药，说不管事儿 -wifi(远方); 2021-12-23 (#14209190@0) +1
          • 改买辉瑞 -shunshunshun(顺顺顺); 2021-12-23 (#14209194@0)
            • 我怀疑是辉瑞势力大、打压莫克。所以辉瑞的药估计也没啥用 -wifi(远方); 2021-12-23 (#14209211@0) +5
              • 我怀疑辉瑞真的有点用，默克未必 -moonhalf(减肥减多久); 2021-12-23 (#14209420@0)
              • 辉瑞做trial的手段高超，疫苗和药都是超高有效率，实战就现原形了。默克比较实诚，疫苗做不出来，药的有效率也做不高。 -blueskygg(Grass); 2021-12-23 (#14209543@0) +4
        • 又把对照组给干掉了，跟疫苗一样，就这一条就值得怀疑。起码ivm安全得多。 -headbig(Let's Rock！); 2021-12-23 (#14209565@0) +1
      • 群体肯定大过人吃兽药的数量。LOL -gr8(老中); 2021-12-23 (#14209186@0) +2
        • 240 millions in Uttar Pradesh, India -sailor(Ocean & Mountain); 2021-12-23 (#14209229@0) +3
          • This is not a scientific experiment. There's no record of the data, no quantitative measurement ( such as side effect, healing rate, time, amount, other consumption, excretion etc). 这跟十四亿人们拍拍脑袋就能当中医是一个样子。 -gr8(老中); 2021-12-23 (#14209625@0)
        • 那未必。别先那么肯定 -utgfxval3(蛙); 2021-12-23 (#14209647@0)
    • 是治疗的药不是疫苗对吧？ -summerday2020(Hopeday); 2021-12-23 (#14209181@0)
    • 诺娃娃克斯批上市了，期待好用 -shunshunshun(顺顺顺); 2021-12-23 (#14209187@0)
      • Novovax 的疫苗是蛋白疫苗， -micah(mica); 2021-12-23 {247} (#14209223@0)
        以往的经验是这种疫苗的免疫原性比较低， 比腺病毒疫苗和RNA疫苗， 效果应该不会更好， 除非这家公司在佐剂上有什么独门绝技。 今后的主流仍然是mRNA疫苗。这些新的疫苗倒是可以解决发展中国家的需要， WHO一再强调疫苗分配的公平性， 这些新的疫苗可以缓解这个问题
        • 希望解决反mRNA疫苗认识的问题 -shunshunshun(顺顺顺); 2021-12-23 (#14209251@0)
    • 22年就靠这个，疫情有可能就过去了。 -xz730000(笑一笑，十年少); 2021-12-23 (#14209193@0) +2
      • 如果辉瑞真的有89%有效率，而且是针对高危人群，那么真的就可以结束疫情了。 -hi12345(12345); 2021-12-23 (#14209495@0)
    • 安省把抗抑郁治疗药列入covid早期治疗名单 -guwangyan(瞎说话); 2021-12-23 (#14209218@0)
      • That's concerning. Anti-depression drugs typically alter brain functions and are addictive. -sailor(Ocean & Mountain); 2021-12-23 (#14209241@0) +1
        • 你能想到的，医生早就考虑过了。这个药也不是新药，副作用比较明确，临床有效率也有65%左右。对于高危的人来说，吃不吃就是生死的选择。再怎么比也比吃兽药强！而且还便宜，一天一刀。 -coolrock(coolrock); 2021-12-23 (#14209256@0) +3
        • 告诉你一个好消息，日本9月开始了一个你们神药的双盲实验，4百万美元资金受神药发明者的委托，为发达国家的第一个，估计年底有结果。 -guwangyan(瞎说话); 2021-12-23 (#14209265@0) +1
          • 下面的链接有小规模兽药治新冠的临床论文，多个国家包括印度，没有一个能够说兽药有效，吃不吃效果不明显。 -coolrock(coolrock); 2021-12-23 {462} (#14209297@0) +2
            Review clinical data on the use of ivermectin for the treatment of COVID-19.
            Full Story:
            https://www.covid19treatmentguidelines.nih.gov/tables/ivermectin-data/
            • 你这话要被批评说造谣的吧，人家蓝天同学早就说了印度某个邦大面积推广神药，已经把病毒消灭了，实现了零新增零死亡，小心蓝天同学跟你急。 -winterfish(潜水鱼(\ (•◡•) /)); 2021-12-23 (#14210502@0)
          • The effectiveness of ivermectin is determined by dose. -sailor(Ocean & Mountain); 2021-12-23 {856} (#14209331@0) +1

            Let's use the anti-malaria drug Malarone as an example. For prevention purpose, the dose is one pill per day. But if the patient contracts the virus, the treatment requires a much higher dose. Dose matters.

            Similarily, the prevention, early treatment, and late treatment of COVID using ivermectin require different doses, ranging from 0.2mg/KG to 0.6mg/KG. Such protocol was made based on clinical experience by frontline doctors at FLCCC.net.

            There are already several ivermectin trials published on the CDC/FDA websites. However, all those trials used much lower doses than the FLCCC protocol. Therefore, the results were not satisfying. CDC/FDA use it as an excuse to prevent the use of ivermectin for COVID.

            So, it's not about whether there is a trial, but about whether the trial makes sense by using effective doses.

          • the Japanese trial started Sept last year. The aim was to recruit 240 patients. One + year later as of today, the trial status still shows recruiting patients. That tells you how enthusiastic the japs feel about IVM. Lol. -micah(mica); 2021-12-23 {424} (#14209357@0)
            Study in COvid-19 Patients With iveRmectin (CORVETTE-01) - Full Text View.
            Full Story:
            https://clinicaltrials.gov/ct2/show/NCT04703205
            • 今年9月兴和制药受发明者北里大学木村智教授委托开始了一个，希望有一个好结果 -guwangyan(瞎说话); 2021-12-23 (#14209578@0)
              • I see. Is this the one? -micah(mica); 2021-12-23 {407} (#14209639@0)
                A Phase III Confirmatory Study of K-237 - Full Text View.
                Full Story:
                https://clinicaltrials.gov/ct2/show/NCT05056883
                • 推广IVM的医生们反复强调IVM要跟VC,VD, Zinc一起吃，治疗至少要吃5天，这个trial只用IVM，只吃3天，不知道说什么好。 -blueskygg(Grass); 2021-12-23 (#14209667@0)
                  • 我来帮你说，很显然这些人受了WHO和疫苗厂商的压力，故意做这种失败的实验。肯定收了钱了。。 -winterfish(潜水鱼(\ (•◡•) /)); 2021-12-23 (#14210508@0)
                • 是这个 -guwangyan(瞎说话); 2021-12-23 (#14210193@0)
            • Ivermectin approximately 200 μg/kg administered as a single oral dose on Day 1 (fasting state) 这个trial只吃一剂IVM，剂量还那么低，就是存心要让它fail的。 -blueskygg(Grass); 2021-12-23 (#14209690@0)
              • 你说的是上面第一个trial 反正也收不到病人 无所谓了。第二个是吃三天 0.3mg/kg. 至于其他嘛 你可以联系他们建议一下 估计也晚了 -micah(mica); 2021-12-23 (#14209707@0)
              • 对，一定要加大剂量，人死不死无所谓，只要把病毒杀死那就是神药有效。 -winterfish(潜水鱼(\ (•◡•) /)); 2021-12-23 (#14210512@0) +1
    • Never trust them anymore! -111111(快乐老家); 2021-12-23 (#14209431@0)
    • what is 默克? -miantiao((面条小狗狗）); 2021-12-23 (#14209504@0)
      • Merk -111111(快乐老家); 2021-12-23 (#14209521@0)
    • 这生意做的。 -utgfxval3(蛙); 2021-12-23 (#14209643@0)
    • 我觉得辉瑞的ceo面相看起来就是个坏蛋样 -whiteblacktea(黑白茶); 2021-12-23 (#14210472@0)
      • 厉害了，从推特治国，微信公众号治国，中医药治国，现在又来了相面治国，肉联真是藏龙卧虎，能人无数。。 -winterfish(潜水鱼(\ (•◡•) /)); 2021-12-23 (#14210495@0)
    • 呵呵，疫苗也曾经95%有效，预计半年前结束疫情哦 -itwriting(halfpercent); 2021-12-23 (#14210516@0) +1

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